Stereocontrolled organocatalytic synthesis of prostaglandin
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We built a GB1 library where each variant contained a single glutamine at positions covering all secondary structure elements. The most reactive and selective variants displayed a 100-fold increase in incorporation of a recently developed aminated benzoaimidazo2,1,5-cdindolizine-type fluorophore, relative to native GB1. M is a national, medical coding, training.
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